|
KMID : 1059519930370050527
|
|
Journal of the Korean Chemical Society
1993 Volume.37 No. 5 p.527 ~ p.536
|
|
|
Preparation and Evaluation of Antibacterial Transdermal Device using Chitosan Matrices
|
|
Kim Sun-Il
Na Jae-Woon
|
|
|
Abstract
|
|
|
|
The characteristics of the controlled drug release were studied for biodegradable transdermal drug delivery system. A biodegradable polymeric matrix was prepared from chitosan, silver sulfadiazine, and glycerine. The release behavior of silver sulfadiazine from chitosan matrix was consistent with the Higuchi's diffusion controlled model. The release time was delayed by increasing the content of silver sulfadiazine and thickness of the matrix, whereas decreased as glycerine concentration increased. The apparent constant (K) of release rate was proportional to the content of drug or glycerine and the thickness of chitosan matrix. These results indicated that chitosan matrix shows some potential as a drug delivery system for transdermal therapeutic application.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|